Related to Figs 1, 2 and S1.

Sheet A in S1 Table (Fig 1): Median log2TPM (transcripts per million) RNA-Seq values for forty-eight human core ISGs and thirty-eight human interferons/interferon receptors across fifty-four tissues. HLA was excluded as it is a multi-copy gene. RNA-Seq data were retrieved from GTEx Analysis V8 (https://gtexportal.org/home/datasets). Core ISG designation from [39]. Interferons and interferon receptors were retrieved from The HUGO Gene Nomenclature Committee (HGNC) Gene group reports (https://www.genenames.org/data/genegroup/#!/). Sheet B, C, D, and E in S1 Table (Fig 2): Log2TPM (transcripts per million) RNA-Seq values and statistics for representatives from ISG subclasses ‐ 2 high, 2 low, and 5 variable ‐ across 578 human lung tissue samples (Sheet B in S1 Table), 226 human liver tissue samples (Sheet C in S1 Table), 241 human spleen tissue samples (Sheet D in S1 Table), and 755 human whole blood tissue samples (Sheet E in S1 Table). RNA-Seq data were retrieved from GTEx Analysis V8 (https://gtexportal.org/home/datasets). Core ISG designation is from [39]. Statistics table was generated using python pandas library (https://pandas.pydata.org/). Sheet F in S1 Table (S1 Fig): Gene list used for pathway analysis of tonic ISG subclasses. Total of forty-seven core ISG genes from Fig 1. Average RNA-Seq log2 fold-change were obtained from [39]. SAT1 was deemed an outlier and excluded along with interferons and interferon receptors. Core ISGs are classified into three clusters based on their expression level across tissues. Pathway analysis was performed using QIAGEN IPA (QIAGEN Inc., https://digitalinsights.qiagen.com/IPA) with ID and log2 fold-change expression values. ISG–interferon-stimulated gene
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