Cutaneous Epstein-Barr Virus-Positive Diffuse Large B-cell Lymphoma, not otherwise specified: A systematic review and comparative analysis with Epstein-Barr Virus-negative, leg type

Supplement 1. PRISMA flow diagram of literature search and study selection.
EBV+ DLBCL, NOS, Epstein-Barr Virus-positive diffuse large B-cell lymphoma, not otherwise specified; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Supplement 2. Histopathological features of cutaneous Epstein-Barr Virus-positive diffuse large B-cell lymphoma, not otherwise specified. (A) Pleomorphic atypical large cells in a background rich in reactive cells such as lymphohistiocytes and plasma cells (hematoxylin and eosin, x200). (B) Monotonous sheets of immunoblast-like large cells (hematoxylin and eosin, x200). Atypical large lymphoid cells of cutaneous Epstein-Barr Virus-positive diffuse large B-cell lymphoma, not otherwise specified highlighted by (C) MUM-1 (x200), (D) BCL-2 (x200), and (E) CD30 (x200); Epstein-Barr Virus infection detected by (F) positive Epstein-Barr encoding region in situ hybridization (x200).

Supplement 3. Survival analysis of cutaneous Epstein-Barr Virus-positive diffuse large B-cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS). (A) Difference in overall survival between primary cutaneous EBV+ DLBCL, NOS and primary cutaneous Epstein-Barr Virus-negative diffuse large B-cell lymphoma, leg type (EBV- DLBCL, leg type). (B) Comparison in survival between primary cutaneous EBV+ DLBCL, NOS and concurrent cutaneous and extracutaneous EBV+ DLBCL, NOS.

补充1：文献检索和研究选择的PRISMA流程图。EBV+ DLBCL, NOS，即未另作说明的EBV阳性弥漫性大B细胞淋巴瘤；PRISMA，系统评价和Meta分析报告项目。补充2：未另作说明的皮肤EBV阳性弥漫性大B细胞淋巴瘤的病理学特征。（A）在富含反应性细胞如淋巴组织细胞和浆细胞的背景下，存在多形性的非典型大型细胞（苏木精和伊红染色，放大倍数200倍）。（B）由免疫母细胞样大型细胞构成的均质片状结构（苏木精和伊红染色，放大倍数200倍）。未另作说明的皮肤EBV阳性弥漫性大B细胞淋巴瘤的非典型大型淋巴细胞通过（C）MUM-1（放大倍数200倍）、（D）BCL-2（放大倍数200倍）和（E）CD30（放大倍数200倍）进行突出显示；通过（F）原位杂交检测到的EBV感染阳性EB编码区域（放大倍数200倍）。补充3：未另作说明的皮肤EBV阳性弥漫性大B细胞淋巴瘤（EBV+ DLBCL, NOS）的生存分析。（A）原发性皮肤EBV+ DLBCL, NOS与原发性皮肤EBV阴性弥漫性大B细胞淋巴瘤，腿部类型（EBV- DLBCL，腿部类型）在总生存率上的差异。（B）原发性皮肤EBV+ DLBCL, NOS与同时性皮肤和皮肤外EBV+ DLBCL, NOS在生存率上的比较。