Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with Carfilzomib

Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with Carfilzomib Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ... Authors: Huber, E.M, Heinemeyer, W, Groll, M. Deposit date: 2025-03-03 Release date: 2025-10-08 Last modified: 2025-12-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity. Structure, 33, 2025酵母20S蛋白酶体突变体：β5_G128V（反式形式的b5前肽）与卡非佐米（Carfilzomib）结合形成的复合物。描述符：(4S)-2-甲基-2,4-戊二醇、2-(N-吗啉代)乙磺酸、3-吡啶-4-基-2,4-二氢-茚并[1,2-c]吡唑……作者：Huber, E.M.、Heinemeyer, W.、Groll, M.。存储日期：2025-03-03；发布日期：2025-10-08；最后修改日期：2025-12-17。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9埃。引用文献：《蛋白酶体相关自身炎症综合征：蛋白酶体亚基突变对颗粒组装、结构与活性的影响》，《Structure》，第33卷，2025年。