Proteomic data of the perinatal pig brain

The uploaded proteome data were obtained from 336 samples of perinatal Bama miniature pigs, covering multiple time points and brain regions. Analyzed with transcriptome data, they revealed the spatiotemporal organization of perinatal molecular profiles and gene-protein expression concordance. These data helped confirm perinatal Bama miniature pigs as an optimal large-animal model for human perinatal neurodevelopment (closer to humans than mice). They also identified a pan-regional developmental inflection point (E94-E104) with dramatic changes in proteins related to synaptogenesis and gliogenesis, supported analyses of regional developmental heterogeneity, and facilitated studying brain disorder risk gene transitions, serving as a key part of the multi-omics atlas for decoding neurodevelopmental pathogenesis.