JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE
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JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE Descriptor: Tyrosine-protein kinase JAK2, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile Authors: Eigenbrot, C, Shia, S. Deposit date: 2013-01-22 Release date: 2013-05-22 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J.Med.Chem., 56, 2013
JAK2激酶（JAK2 kinase）的JH1结构域与抑制剂反式-4-[(8AS)-2-[(1R)-1-羟乙基]咪唑并[4,5-d]吡咯并[2,3-b]吡啶-1(8AH)-基]环己烷甲腈的复合物
描述：酪氨酸蛋白激酶JAK2（Tyrosine-protein kinase JAK2），反式-4-{2-[(1R)-1-羟乙基]咪唑并[4,5-d]吡咯并[2,3-b]吡啶-1(6H)-基}环己烷甲腈
作者：Eigenbrot, C、Shia, S.
存放日期：2013-01-22
发布日期：2013-05-22
最后修改日期：2024-11-20
实验方法：X射线衍射（1.5 Å）
引用：《C-2羟乙基咪唑并吡咯并吡啶类强效JAK1抑制剂的鉴定：兼具优良理化性质与对JAK2的高选择性》，J.Med.Chem., 56, 2013
创建时间：
2013-01-22
