ß-catenin deficiency in hepatocytes promotes liver tumorigenesis driven by oncogenic ß-Catenin and c-Met in mice

To understand differential gene expression globally with/without hepatocyte ß-catenin knockout on liver cancer mouse model, RNA-seq analysis were examined using hydrodynamic ß-catenin and c-Met induced ß-catenin?H (ß-cateninF/F:Alb-cre) and WT mice. Overall design: Total RNA extracts from liver on 2-month-old mice, 3 days and 7 weeks after ß-catenin and c-Met injection of ß-catenin KO and WT mice, Group 1: 2-month-old mice (n=3); Group 2: 2-month-old ß-catenin KO mice (n=3); Group 3: 3 days after ß-catenin and c-Met injection of WT mice (n=3); Group 4: 3 days after ß-catenin and c-Met injection of ß-catenin KO mice (n=3); Group 5: 7 weeks after ß-catenin and c-Met injection of WT mice (n=3); Group 6: 7 weeks after ß-catenin and c-Met injection of ß-catenin KO mice (n=3).