The_Surveillance_for_Enteric_fever_in_Asia_Project__SEAP_

The Surveillance for Enteric fever in Asia Project (SEAP) is a prospective study aimed at characterizing the burden of enteric fever in Bangladesh, Nepal and Pakistan through hospital and enhanced laboratory-based surveillance, longterm case follow-up, and health care utilization surveys. The overall study objectives include describing the clinical manifestations, severity of illness, long-term sequelae of illness, risk factors for disease, cost of illness, and antimicrobial resistance patterns of enteric fever isolates. Whole-genome sequencing of 3,000 enteric fever isolates collected through the SEAP surveillance system will generate critical information to gain insight into epidemiologic transmission patterns, further characterize the current and the evolving patterns of antimicrobial resistance, and add to the understanding of the relationship between genetics and disease severity. These sequences will also serve as the baseline in evaluations of future mass typhoid vaccination campaigns to assess if the vaccine has an impact on circulating strains.