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Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. Walls, Fiala et al.

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NIAID Data Ecosystem2026-03-12 收录
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Walls, Fiala et al describe a self-assembling protein nanoparticle displaying the SARS-CoV-2 receptor-binding domain in a highly immunogenic array eliciting diverse, potent and protective antibody responses. The nanoparticle vaccines induce neutralizing antibody titers ten-fold higher than the prefusion-stabilized spike ectodomain trimer using a five-fold lower dose.

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2020-10-23
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