首页/数据集/Life-supporting function of genome edited porcine renal graft in cynomolgus macaques. Life-supporting function of genome edited porcine renal graft in cynomolgus macaques

Life-supporting function of genome edited porcine renal graft in cynomolgus macaques. Life-supporting function of genome edited porcine renal graft in cynomolgus macaques

NIAID Data Ecosystem2026-03-13 收录

异种移植

基因编辑猪肾移植

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA870308 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2022-08-17

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异体移植肝细胞测序数据

异种移植

基因编辑

（1）利用CRISPR/Cas9系统构建Fah–/–Rag2–/–IL2rg–/− （FRG）大鼠，并鉴定其在撤去NTBC水后是否可以发生肝脏损伤。（2）将小鼠肝细胞移植到FRG大鼠，证明FRG大鼠模型可应用于异种肝细胞移植。（3）将人肝细胞移植到FRG大鼠中，建立可控性肝损伤预处理模型，使大鼠肝脏达到30%人源化（4）通过基因表达、蛋白染色和药物代谢，证明肝脏人源化大鼠具有人类肝脏代谢特征。

干细胞与再生医学数据中心2023-04-27 更新170

Investigation of tumorigenicity frequency of CD133 + and CD133 − cells derived from four AT/RT patients in NOD/SCID xenotransplant assay.

肿瘤研究

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Investigation of tumorigenicity frequency of CD133+ and CD133− cells derived from four AT/RT patients in NOD/SCID xenotransplant assay.

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Combined transgenic expression of α-galactosidase and α1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galα(1,3)Gal

异种移植

免疫调控机制

Hyperacute rejection of pig organs by humans involves the interaction of Galα(1,3)Gal with antibodies and complement. Strategies to reduce the amount of xenoantigen Galα(1,3)Gal were investigated by o

PubMed Central1997-12-23 更新10

Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation. Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation

异种移植

分子生物学

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

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Short tandem repeat (STR) analysis demonstrating unique genetic identity of each xenograft.

STR分析

异种移植

*Number of repeats on each chromosome at each of 15 tetranucleotide repeat loci for each xenograft are shown along with patient sex determination by amplification of the Amelogenin gender determining

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