Summary Statistics: Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

Exome wide gene and single variant level summary statistics associated with the Nature Communications article "Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases".

Gene Level Association Files

gene_level_prostate_cancer_risk.txt: gene-level summary statistics for assocation with prostate cancer risk (case Vs controls)

gene_level_prostate_cancer_severity.txt: gene-level summary statistics for assocation with prostate cancer severity (aggressive prostate cancer Vs non-aggressive prostate cancer)

gene_level_prostate_cancer_agg_ctrl.txt: gene-level summary statistics for assocation of aggressive prostate cancer Vs controls

Columns

Gene Name

Gene ENSG - Ensembl gene ID

CA_model - collapsing analysis qualifying variant model (as in Supplementary Data 1 of article)

CMH_P - meta analysis P-value

CMH_OR - meta analysis odds ratio

CMH_OR_LCI - meta analysis odds ratio lower confidence interval

CMH_OR_UCI - meta analysis odds ratio upper confidence interval 

Total Qual Cases - number of cases carrying a qualifying variant

Total Unqual Cases - number of cases not carrying a qualifying variant

Total Qual Ctrls - number of controls carrying a qualifying variant

Total Unqual Ctrls - number of controls not carrying a qualifying variant

Single Variant level Association File

single_variant_prostate_cancer_risk.txt - single variant level summary statistics for assocation with prostate cancer risk (case Vs controls)

Columns

chr - chromosome

pos - genomic position

effect_allele

other_allele

P - meta analysis P-value

direction - direction of effect in individual cohorts (100KGP,  MCPS, UKB_SAS,  UKB_AFR, UKB_EUR, FinnGen).