Alternative Model Settings.

The model fit and outcomes (post-vaccination prevalence) under different model assumptions about duration of natural immunity (1/w), weight of the secondary force of infection (γ base-case = 0.4), increased new partner acquisition rate for young adults (+20% partners), and different natural immunity waning model (SIS) only for males. The measure of model fit is a weighted sum of squared residuals (WSR). The calibrated model parameters: clearance rate of persistent infection (ηpers), transmission probability per partnership (β), waning rate of natural immunity (w). The mean and standard deviation (SD) are given for each parameter. The high-risk HPV (hrHPV) infection includes both transient and persistent infections (pers.inf.).