Results of dynamic susceptibility contrast perfusion MRI and clinical scales in 36 patients with multiple sclerosis.

The research objective for these data was to find correlations between brain regional perfusion changes in patients with multiple sclerosis and particular clinical symptoms. 36 patients with multiple sclerosis and 7 healthy volunteers underwent accessment with clinical scales and questionaires and dynamic susceptibility contrast perfusion MRI. Perfusion values were measured in 16 regions of interest in brainstem, basal ganglia and hemispheres. Measurements of Cerebral Blood Volume (CBV) and Cerebral Blood Flow (CBF) in lenticular nuclei bilaterally showed significant reduction in patients with all levels of disability comparing with healthy controls. Significant negative correlation was found between CBF in lenticular nuclei bilaterally and fatigue rates (measured by the Fatigue Severity Scale (Krupp, La Rocca et al, 1989)) . Further research on bigger samples can be helpful in finding new correlations between brain perfusion changes and particular clinical symptoms for better understanding of the underlying pathological mechanisms and developing new treatment approaches.

本数据集的研究目标为探究多发性硬化（multiple sclerosis）患者的脑区域灌注变化与特定临床症状之间的相关性。研究对36名多发性硬化患者与7名健康志愿者开展了临床量表评估、问卷调查以及动态磁敏感对比灌注磁共振成像（dynamic susceptibility contrast perfusion MRI）检查。研究人员对脑干、基底神经节与大脑半球内的16个感兴趣区（regions of interest）的灌注值进行了测量。对双侧豆状核的脑血容量（Cerebral Blood Volume, CBV）与脑血流量（Cerebral Blood Flow, CBF）的测量结果显示，相较于健康对照组，各残疾程度等级的患者均出现了显著降低。研究还发现，双侧豆状核的脑血流量与疲劳评分（采用疲劳严重度量表（Fatigue Severity Scale，Krupp、La Rocca等人于1989年编制）进行评估）之间存在显著负相关关系。后续可扩大样本量开展进一步研究，以挖掘脑灌注变化与特定临床症状间的新关联，从而更好地解析其潜在病理机制并开发全新的治疗方案。