Effect of Bartonella on ECs angiogenesis kinetics.

Acceleration of the pseudovessel rearrangement induced by infection with B. henselae strains or their supernatants was observed only with human microvasculature-derived ECs (HSkMEC). In feline cells, bacterial infection accelerates the network destruction. Noticeably, uninfected human ECs from micro- and macro-vasculature display differences in the angiogenesis kinetics.Similar results were obtained when ECs were treated by corresponding B. henselae supernatants.Results from one out of four independent experiments are shown.Human Macrovascular EC: immortalized Human Umbilical Vein Endothelial Cells (iHUVEC); Human Microvascular EC: Human Skin Microvascular Endothelial Cells (HSkMEC); Feline Macrovascular EC: Feline Umbilical Vein Endothelial Cells (FOmEC); Feline Microvascular EC: Feline Skin Microvascular Endothelial Cells (FSkMEC).