Silyl-Group-Directed Linear-Selective Allylation of Carbonyl Compounds with Trisubstituted Allylboronates Using a Copper(I) Catalyst
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https://figshare.com/articles/dataset/Silyl-Group-Directed_Linear-Selective_Allylation_of_Carbonyl_Compounds_with_Trisubstituted_Allylboronates_Using_a_Copper_I_Catalyst/11796192
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资源简介：
A copper(I)-catalyzed
linear-selective allylation of carbonyl compounds
with trisubstituted allylboronates has been achieved by capitalizing
on the electronic and steric effects of silyl groups. This reaction
provides stereodefined trisubstituted homoallyl alcohol derivatives
that bear a synthetically useful alkenyl silane moiety. The results
of a computational study suggested that the silyl directing group
thermodynamically stabilizes
the sterically hindered allylcopper(I) intermediate and kinetically
facilitates the carbonyl allylation path for the linear product by
lowering the energy of its transition state.
创建时间：
2020-01-15
