IMPROVE Anti-inflammatory effects of sulphadoxine-pyrimethamine for intermittent preventive treatment for malaria in pregnancy (GHDC-SI-ID-45)

The Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa (IMPROVE) study is a 3-arm malaria chemoprevention trial with monthly intermittent preventive treatment in pregnancy, or IPTp, in Malawi, Kenya and Tanzania (Clinicaltrials.gov: NCT03208179Trial). Using Olink, we profiled plasma cytokine levels in pregnant women at enrolment, around 28 weeks and 36 weeks (or delivery) at Stanford's Human Immune Monitorin Center (HIMC).