Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

ChEBI2015-12-11 更新2026-07-12 收录

纤维化机制

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Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

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2015-12-11

Multimodal learning of noncoding variant effects using genome sequence and chromatin structure

变异功能预测

表观遗传调控

ncVarPred-1D3D: pretrained models of Sei (PMID: 35817977) + our 3D structure embedding models are shared. The models are trained and validated using DeepSEA (PMID: 26301843) selected 200 bp regions (w

Zenodo2023-08-08 更新00

The top 10 active ingredients.

纤维化机制

中药活性成分

A number of studies demonstrate the therapeutic effectiveness of Radix Bupleuri (RB) and Hedysarum Multijugum Maxim (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear.

NIAID Data Ecosystem00

ZDHHC15 mediates Hippo/YAP pathway palmitoylation and regulates tumor progression [TOV-112D]. ZDHHC15 mediates Hippo/YAP pathway palmitoylation and regulates tumor progression [TOV-112D]

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YAP信号通路

The Post-translational modification of Hippo/YAP pathway members plays an important role in regulating the activation of Hippo/YAP pathway and its effects in tumors. S-Palmitoylation, also known as S-

NIAID Data Ecosystem00

ChIP Seq of influenza specific primary, memory and secondary CD4+ T cells [InVitro]

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CD4+T细胞记忆

Immune responses to infection involve a careful balance: too weak a response allows pathogen replication; too strong risks immunopathology. The immunoregulatory cytokine IL-10 is a key factor in this

NIAID Data Ecosystem00

DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation [RNA-seq]

表观遗传调控

甲基化反应机制

DNA methylation at the 5-position of cytosine (5mC) is a crucial epigenetic mark in regulating biological processes including gene silencing, gene imprinting, and X chromosome inactivation. It has lon

NIAID Data Ecosystem00

Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

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