Discovery of IRAK4 Inhibitor 23

Discovery of IRAK4 Inhibitor 23 Descriptor: Interleukin-1 receptor-associated kinase 4, ~{N}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{R})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide Authors: Schafer, M, Bothe, U, Schmidt, N, Gunther, J, Nubbemeyer, R, Siebeneicher, H, Ring, S, Boemer, U, Peters, M, Denner, K, Himmel, H, Sutter, A, Terebesi, I, Lange, M, Wenger, A.M, Guimond, N, Thaler, T, Platzek, J, Eberspaecher, U, Steuber, H, Steinmeyer, A, Zollner, T.M. Deposit date: 2022-08-23 Release date: 2023-09-06 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.464 Å) Cite: Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 . J.Med.Chem., 67, 2024IRAK4抑制剂23的发现 描述：白介素-1受体相关激酶4（Interleukin-1 receptor-associated kinase 4, IRAK4），N-[6-甲氧基-2-(2-吗啉-4-基-2-氧代乙基)吲唑-5-基]-6-[(1R)-2,2,2-三氟-1-羟基乙基]吡啶-2-甲酰胺 作者：Schafer, M、Bothe, U、Schmidt, N、Gunther, J、Nubbemeyer, R、Siebeneicher, H、Ring, S、Boemer, U、Peters, M、Denner, K、Himmel, H、Sutter, A、Terebesi, I、Lange, M、Wenger, A.M、Guimond, N、Thaler, T、Platzek, J、Eberspaecher, U、Steuber, H、Steinmeyer, A、Zollner, T.M. 存档日期：2022-08-23 发布日期：2023-09-06 最后修改日期：2026-03-04 测试方法：X射线衍射（分辨率2.464埃） 引用文献：《IRAK4抑制剂BAY1834845（扎贝多塞替尼/Zabedosertib）与BAY1830839的发现》，《药物化学杂志（Journal of Medicinal Chemistry）》，第67卷，2024年