MetaDrugSig

MetaDrugSig is a transcriptomic drug signature database containing consensus gene expression signatures for 1,009 drugs, generated from 4,312 comparisons across 4,013 GEO series. Drug signatures were computed using restricted maximum likelihood (REML) random-effects meta-analysis for drugs with ≥2 independent studies (Tier 1) or edgeR differential expression for single-study drugs (Tier 2). The database covers 66,437 genes and includes per-gene uncertainty metrics (standard error, heterogeneity estimates) not available in existing resources.