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Temporal control of species-specific motor neuron differentiation [Mm]

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP230808
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How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem cell (hESC) and mouse stem cell (mESC) differentiation to motor neurons through detailed RNA-sequencing time courses, we wish to find if there is a global scaling factor between species Overall design: RNA samples from mouse and human in vitro differentiations. Human and mouse stem cells monolayer differentiations towards motor neurons upon addition of Retinoic Acid and a Sonic Hedgehog agonist. Mouse samples were collected every 12h for the first three days and daily up to day 7 in triplicates. Human samples are collected daily in triplicates up to day 15.
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2020-12-19
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