Cellular stress response of Sulfolobus acidocaldarius to nutrient limitation

This study provides novel insights into archaeal stress response. The effect of nutrient limitation on the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius was monitored over time on transcriptomic, proteomic and metabolic level. To our knowledge, this linkage of transcriptome, proteome, metabolome analysis makes this study a pioneer study to elucidate cellular stress response triggered by nutrient limitation. We further connect previously identified pH and salt stress responsive genes (1) with genes regulated in starvation and suggest that they constitute the core of stress responsive genes active under multiple stress sources. Overall design: Differential gene expression analysis for transcriptomes of S.acidocaldarius MW001 before and 0.5, 1.5, 2 and 4 h after exposure to nutrient limitation; Three biological replicates per sample