Tissue-autonomous pharmacological direction and the Tissue Direction Index (TDI): analysis code and data for the hemostatic proof-of-concept

Analysis code, prepared molecular-docking input structures, and derived result datasets supporting two manuscripts on tissue-autonomous pharmacological direction (TAPD) and the Tissue Direction Index (TDI):(1) Chen H, Chen Q, Wang Y. Tissue-autonomous pharmacological direction: how target expression landscapes convert balanced compounds into tissue-selective agents. Frontiers in Pharmacology (2026), Vol. 17. DOI: 10.3389/fphar.2026.1870571 (in production; the DOI activates on publication — article page: https://www.frontiersin.org/articles/10.3389/fphar.2026.1870571/full)(2) Chen H, Chen Q, Wang Y. An expression-weighted docking framework for exploring tissue-dependent direction of multi-target compounds, illustrated on hemostatic regulation (under review).The study is entirely computational. The package contains all scripts (by analysis phase), Phase-1 compound–target tables, molecular docking inputs/outputs (6 compounds × 25 hemostatic targets), and all derived result tables. Third-party raw databases (GEO GSE16561 and GSE66407; GTEx v8; TCMSP) are not redistributed; data_sources.md documents how to obtain them. See README.md for the repository layout and reproduction instructions.