Autopsy report summary of patients who died of severe CNS (s-CNS) cryptococcosis.

Cryptococcus autopsy cases for brain immunhistochemistry that have been collated according to the following inclusion criteria based on findings 1 week prior to death: (1.) cryptococcal meningoencephalitis with or without dissemination (CSF India ink OR culture positive), (2.) Glasgow coma score 48 hours, (3.) presence of Babinski or other upper motor neuron signs OR seizure activity, and (4.) exclusion of competing risks.PMN = polymorphonuclear leukocytes*PCR of our paraffin embedded brain autopsy specimens revealed C. neoformans in all 5 autopsy specimens.**tapered off by time of death1 in remissionAutopsy report summary of patients who died of severe CNS (s-CNS) cryptococcosis.