Research data supporting 'The osteoarthritis associated sphingolipid sphingomyelin 34:1 causes inflammatory pain in mice'.

Each .csv file contains the raw data and metadata obtained from either in vitro (electrophysiology) or in vivo (behavioural) experiments. An explanation of how data under each column was collected/analysed follows: Exp = Metadata (set of experiments data pertain to). Condition = Experimental group (i.e. the lipid injected (invivo) or used to stimulate cells (in vitro). Cohort = Metadata. Mouse = Metadata (Mouse identifier). Timepoint_h = Time at which data collected (post intra articular injection). AvgDiggingTime_s = The average of the time (s) mice spent digging reported by multiple experimenters. Digging_Burrows = No. of visible burrows present after a three minute recording of mice. IpsiKneeWidth_mm = Width of the injected knee joint (mm) as measured with digital callipers. ContraKneeWidth = Width of the non-injected knee joint (mm) as measured with digital callipers. Weight_g = Weight of the animal (g). IpsiPAM_g = Mechanical threshold of the injected knee joint as assessed by Pressure Application Measurement, reported data are an average of two independent tests). Rotarod_s = Time (s) mice remained on the rotarod apparatus during testing. Cell = Metadata (Cell identifier). Cap_pF = Cellular capacitance (pF) from electrophysiology. RMP_mV = Resting membrane potential (mV) from current-clamp electrophysiology. Rheo_pA = Rheobase (pA) from current-clamp electrophysiology. PeakAmplitude_mV = Peak amplitude (mV) of analysed action potential from current-clamp electrophysiology. HPD_ms = Half-peak duration (ms) of analysed action potential from current-clamp electrophysiology. AHPAmp_mV = Amplitude of after-hyperpolarisation phase (mV) of analysed action potential from current-clamp electrophysiology. AHP_ms = Tau of after-hyperpolarisation phase (ms) of analysed action potential from current-clamp electrophysiology. Conc = Concentration of lipid stimulant. Sex = Metadata (biological sex of animal). Any questions regarding interpretation of deposited data can be addressed to [e-mail].