File S1 - CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

Contains the following files: Figure A: Photon flux values for (A) CXCR4-CBRN and (B) CXCR7-CBGN corresponding to Fig 3A, 3B. Figure B: Molecular Species Contributing to Beta-arrestin 2 Recruitment. Figure C: Recruitment kinetics of 2x β-arrestin 2, 1x β-arrestin 2 and parental CXCR4+-CXCR7+ complementation cell lines. Figure D: Photon flux values for recruitment of β-arrestin 2-CBC to CXCR4-CBRN in 2x β-arrestin 2 and 1x β-arrestin 2 cells corresponding to Fig 6C. Figure E: Effect of Changing Receptor Numbers on Beta-arrestin Recruitment to CXCR4 and CXCR7 in Co-expressing Cells. Figure F: Expanded Sensitivity Analysis for β-arrestin 2 recruitment to CXCR4 and CXCR7 in Co-expressing Cells. Table A: Validation of receptor expression by qRT-PCR. Table B: Model Equations. Table B1: Equations for cellular events. Table B2: CXCR4+ Cells. Table B3: CXCR7+ Cells. Table B4: CXCR4+-CXCR7+ Cells. Table C: Cell-surface receptor numbers in CXCR4+, CXCR7+, and CXCR4+-CXCR7+ cells. Table D: Results of Sensitivity Analysis.
(PDF)