Lactate Dehydrogenase in complex with inhibitor 6-(3-aminophenyl)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one

Lactate Dehydrogenase in complex with inhibitor 6-(3-aminophenyl)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one Descriptor: (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... Authors: Ultsch, M, Eigenbrot, C. Deposit date: 2017-10-16 Release date: 2018-10-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published

与抑制剂6-(3-氨基苯基)-3-((2-氯苯基)硫基)-4-羟基-6-(噻吩-3-基)-5,6-二氢-2H-吡喃-2-酮结合的乳酸脱氢酶（Lactate Dehydrogenase）。结构描述：(6R)-6-(3-氨基苯基)-3-[(2-氯苯基)硫基]-4-羟基-6-(噻吩-3-基)-5,6-二氢-2H-吡喃-2-酮、4-(2-羟乙基)-1-哌嗪乙磺酸（4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID）、L-乳酸脱氢酶A链……作者：Ultsch, M、Eigenbrot, C. 沉积日期：2017-10-16；发布日期：2018-10-24；最后修改日期：2023-10-04。解析方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.05埃）。引用文献：《结构导向优化人类乳酸脱氢酶羟基内酯与羟基内酰胺抑制剂及其体内活性》（待发表）