The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease
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The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease Descriptor: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE Authors: Yan, L, Ren, Z. Deposit date: 2020-09-18 Release date: 2021-11-03 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease Protein cell, 4, 2013
新型类SARS冠状病毒HCoV-EMC亦存在一处"阿喀琉斯之踵"：当前存在可靶向3C样蛋白酶（3C-like protease）的有效抑制剂。
描述符：3C样蛋白酶抑制剂 N-[(5-甲基异恶唑-3-基)羰基]丙氨酰-L-缬氨酰-N~1~-((1R,2Z)-4-(苄氧基)-4-氧代-1-{[(3R)-2-氧代吡咯烷-3-基]甲基}丁-2-烯基)-L-亮氨酰胺
作者：Yan, L、Ren, Z
提交日期：2020-09-18
发布日期：2021-11-03
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.2 Å
引用文献：《新型类SARS冠状病毒HCoV-EMC亦存在"阿喀琉斯之踵"：靶向3C样蛋白酶的有效抑制剂》，Protein Cell，第4卷，2013年
创建时间：
2020-09-18
