Advancements in Biological Conversion of C1 Feedstocks: Sustainable Bioproduction and Environmental Solutions

The use of one-carbon (C1) feedstocks,
including carbon
dioxide
(CO2), carbon monoxide (CO), formate (HCO2H),
methanol (CH3OH), and methane (CH4), presents
a significant opportunity for sustainable bioproduction and environmental
conservation. This Perspective explores the development of biological
methods for converting C1 feedstocks into valuable products, emphasizing
major progress from engineering native C1 assimilation pathways to
the creation of synthetic autotrophs and methylotrophs that utilize
these carbon sources. Additionally, we discuss hybrid approaches that
merge biological and electrochemical systems, particularly for the
conversion of CO2. This Perspective underscores the importance
of C1 bioconversion in promoting sustainable biotechnological strategies
for a low-carbon future.