The expression profile of circRNA, lncRNA and mRNA in the testis of STZ-induced diabetic rats

The number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual dysfunction. We thus explored the role of circRNA, lncRNA and mRNA in diabetic testicular damage, and revealed that they could serve as effective prevention and treatment therapeutic targets. Streptozotocin (STZ) was used to generate a rat model of type 2 diabetes. Rat testicular tissues were used for circRNA, lncRNA and mRNA sequencing. Testicular tissues circRNA, lncRNA and mRNA profiles of rat after 8 weeks of STZ-induced diabetes were generated by high-throughput sequencing using Illumina Hiseq 3000.