Fig 4: Impact of prolonged sleep/wake on mEPSC frequency

MEPSC frequency is not consistently modulated by sleep/wake history across brain regions. (A) Data from visual cortex L2/3. Left plot, cell average mEPSC frequencies for the indicated conditions; error bars = 95% CI of mean (p=0.75, Kruskal Wallace). Right plot, cumulative plot of inter event interval (SD - L. WD p=0.35, SD - D. WD p=0.15, L. WD - D. WD p>0.9; KS test with Bonferroni correction). Sleep dense n = 17 cells, 3 animals; L. wake dense n = 25 cells, 4 animals; D. wake dense n = 18 cells, 5 animals. (B) Same as in (A) but data from visual cortex L4; cell average on left (p>0.9, Kruskal Wallace); cumulative plot on right (p=0.45, KS test). Sleep dense n = 47 cells, 6 animals; L. wake dense n = 32 cells, 4 animals. (C) Same as in (A) but data from prefrontal cortex L2/3. Left, cell average values for the indicated conditions (p=0.056, Kruskal Wallace). Cumulative plot of inter-event interval (SD - L. WD p<1e-6, SD - D. WD p=0.74, L. WD - D. WD p=0.007; KS test with Bonferroni correction). Sleep dense n = 31 cells, 6 animals; L. wake dense n = 28 cells, 5 animals; D. wake dense n = 18 cells, 6 animals.