CGH of Plasmodium falciparum selected with DSM1
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37306
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资源简介：
Continual challenge of 107 ARMD Dd2 parasites with 0.3µM DSM1, a novel dihydroorotate dehydrogenase (DHODH) inhibitor, reproducibly generated ~5-fold resistance and 3-fold amplification of 30-100Kb DNA, always including the DHODH gene. Subsequent 3-10µM DSM-1 pressure selected for ~10-fold amplification of the copy number variant (CNV), and over 100-fold resistance. Target-specific and genome-wide DNA sequencing revealed no additional mutations contributing to DSM1 resistance. Each DSM1-resistant clone is compared to the Dd2 parent reference sample.
创建时间：
2013-07-31
