File S1 - Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

Supporting figures. Figure S1, Table summary of the effects of D2 drugs on the complementary categories of the elevated plus-maze. Effects of intra-IC injections of vehicle, quinpirole 1.0 µg/0.2 µL or 2.0 µg/0.2 µL and vehicle and 1.0, 2.0 or 4.0 µg/0.2 µL sulpiride on the complementary ethological categories of rats submitted to the elevated plus-maze. Figure S2, Table summary of the effects of D1 drugs on the complementary categories of the elevated plus-maze. Effects of intra-IC injections of vehicle, 1.0 or 2.0 µg/0.2 µL SKF-38393, and vehicle or 1.0, 2.0 or 4.0 µg/0.2 µL SCH-23390 on the complementary ethological categories of rats submitted to the elevated plus-maze. Figure S3, D1 drugs in the elevated plus-maze (EPM). Effects of intra-IC injections of vehicle, 1.0 and 2.0 µg/0.2 µL SKF-38393 or vehicle, 1.0, 2.0 or 4.0 µg/0.2 µL SCH-23390 on exploratory behavior of rats submitted to the elevated plus-maze. (A and D) Number of entries in the closed arms of the maze. (B and E) Number of entries in the open arms of the maze. (C and F). % of time spent into the open arms in relation to total. Figure S4, Fos-positive immunohistochemistry in response to aversive acoustic stimuli (AAS). Number of Fos-positive cells in midbrain (A) and telencephalic (B) structures in rats exposed to testing sessions with or without (Control) presentation of AASs. Figure S5, Fos-positive immunohistochemistry in midbrain structures in response to aversive acoustic stimuli (AAS). Photomicrographs of Fos-positive cells (dark dots) in the dmPAG, dlPAG, vlPAG, and IC in rats exposed to testing sessions with and without (Control) AAS presentation. Figure S6, Fos positive immunohistochemistry in telencephalic structures in response to aversive acoustic stimuli (AAS). Photomicrographs of Fos-positive cells (dark dots) in the Cg1, CPu, NAcC and NAcSh of rats exposed to testing sessions with (AAS) or without (Control) AAS presentation. (PDF)