The role of hemostatic agents following dental extractions: a systematic review and meta-analysis

Objective: This study critically evaluated the role of hemostatic agents following dental extractions, and the benefits they add over conventional hemostatic measures.
Materials and methods: a literature search was conducted, including publications that fulfilled the criteria developed based on the PICOS guidelines; Population: patients who receive simple or surgical tooth extractions, Intervention: the use of hemostatic agents following dental extraction, Control: any type of conventional hemostatic measures (i.e. suture, gauze pressure), Outcome: time to achieve hemostasis following tooth removal, postoperative pain, swelling, or bleeding events, and Study design: randomized/controlled clinical trials.
Results: Twenty-eight articles met the inclusion criteria, and 24 were meta-analyzed. Several types of hemostatic agents were used, namely tissue adhesives made from cyanoacrylate or fibrin, tranexamic acid, hemocoagulase, collagen membrane, HemCon dental dressing, epsilon aminocaproic ...