The role of hemostatic agents following dental extractions: a systematic review and meta-analysis

Objective: This study critically evaluated the role of hemostatic agents following dental extractions, and the benefits they add over conventional hemostatic measures. Materials and methods: a literature search was conducted, including publications that fulfilled the criteria developed based on the PICOS guidelines; Population: patients who receive simple or surgical tooth extractions, Intervention: the use of hemostatic agents following dental extraction, Control: any type of conventional hemostatic measures (i.e. suture, gauze pressure), Outcome: time to achieve hemostasis following tooth removal, postoperative pain, swelling, or bleeding events, and Study design: randomized/controlled clinical trials. Results: Twenty-eight articles met the inclusion criteria, and 24 were meta-analyzed. Several types of hemostatic agents were used, namely tissue adhesives made from cyanoacrylate or fibrin, tranexamic acid, hemocoagulase, collagen membrane, HemCon dental dressing, epsilon aminocaproic ...研究目的：本研究批判性评价牙科拔牙术后止血剂的应用价值，及其相较于传统止血措施的额外临床获益。 材料与方法：本研究开展了文献检索，纳入符合基于PICOS原则制定的纳入标准的出版物；研究对象：接受简单拔牙或外科拔牙的患者，干预措施：牙科拔牙术后使用止血剂，对照措施：各类传统止血方案（即缝合术、纱布压迫止血），结局指标：拔牙术后止血达标时间、术后疼痛、肿胀或出血事件，研究设计：随机对照临床试验。 结果：共计28篇文献符合纳入标准，其中24篇被纳入荟萃分析。研究所使用的止血剂类型多样，具体包括氰基丙烯酸酯或纤维蛋白基组织黏合剂、氨甲环酸、血凝酶、胶原膜、HemCon牙科敷料、ε-氨基己酸……