A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host
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Superior to current clinically used reversal agents in terms of efficacy and side effects: The formation of a high-affinity host–guest binary complex (association constant Ka: ca. 107 M−1) between the aminosteroidal guest molecule rocuronium bromide, the most widely used neuromuscular blocking agent in surgery, and a cyclodextrin-based synthetic host molecule (see X-ray crystal structure) results in reversal of the neuromuscular blockade induced by rocuronium bromide.
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SupraBank创建时间：
2021-10-20
