Senataxin resolves R-loops forming at DNA double strand breaks to prevent translocations

ChEBI2018-02-20 更新2026-07-12 收录

DNA损伤修复

R-loop生物学

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-6318 数据链接链接失效反馈

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Senataxin resolves R-loops forming at DNA double strand breaks to prevent translocations

创建时间：

2018-02-20

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

3-methyladenine dna-glycosylase from Archaeoglobus fulgidus

蛋白质结构解析

DNA损伤修复

3-methyladenine dna-glycosylase from Archaeoglobus fulgidus Descriptor: 3-METHYLADENINE DNA-GLYCOSYLASE, GLYCEROL, SODIUM ION Authors: Leiros, I, Nabong, M.P, Grosvik, K, Ringvoll, J, Haugland, G.T, U

Protein Data Bank Japan2023-12-13 更新20

DNA lesions can frequently precede DNA:RNA hybrid accumulation [RNA-seq]

DNA损伤修复

DNA:RNA杂交体

While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed th

NIAID Data Ecosystem10

Supplementary Table S2 from Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

肿瘤基因组学

DNA损伤修复

Supplementary Table S2: Sig3 scores and FGA values in LMS tumor samples. Sig3+ samples are predicted with a classifier trained in WGS LMS data. FGA values are calculated on CNVkit-based copy number pr

Figshare2023-12-15 更新30

p38-MK2 regulate RNA metabolism after UV light-induced DNA damage

DNA损伤修复

转录调控

Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

NIAID Data Ecosystem20

Senataxin resolves R-loops forming at DNA double strand breaks to prevent translocations

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