The differential expression of lncRNAs in wnt/β-catenin pathway activation or inactivation of triple-negative breast cancer.

To screen the associated lncRNAs with wnt/β-catenin pathway activation of TNBC,through lncRNA microarray profiling between activated and inactivated wnt/β-catenin pathway of TNBC tissues, lnc-WAL (wnt/β-catenin associated lncRNA; WAL) was selected as the top upregulated lncRNA in wnt/β-catenin pathway activation compared with the inactivation group. In TNBC, to further identify wnt/β-catenin pathway activation-associated lncRNAs, we carried out one lncRNA tissue microarray to compare the differences between the activation group (n=5) and inactivation group (n=5) of TNBC tissues.