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Long-read sequencing of Plasmodium falciparum clones

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NIAID Data Ecosystem2026-05-01 收录
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Sequence variation among antigenic var genes in Plasmodium falciparum drives ineffective host immune responses to malaria. Using long reads, we detect unexpected var polymorphism within 17 parasite clones from a mutation accumulation experiment. Putatively circular DNA from these clones is strongly enriched for var genes, which appear in numerous alleles separated by recombination and indel events.

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2023-08-13
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