Synthesis of the Tagetitoxin Core via Photo-Stevens Rearrangement
收藏NIAID Data Ecosystem2026-03-06 收录
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The core structure of the RNA polymerase inhibitor tagetitoxin has been synthesized by one-carbon ring expansion of bridged bicyclic monothioacetals. The key steps are intramolecular ylide formation by reaction between the sulfur atom and a pendant diazoester, followed by an efficient photochemical 1,2-rearrangement to give the desired 9-oxa-3-thiabicyclo[3.3.1]nonane ring system.
创建时间：
2008-12-04
