Clockor2: Inferring global and local strict molecular clocks using root-to-tip regression

Molecular sequence data from rapidly evolving organisms are often sampled
at different points in time. Sampling times can then be used for molecular
clock calibration. The root-to-tip (RTT) regression is an essential tool
to assess the degree to which the data behave in a clock-like fashion.
Here, we introduce Clockor2, a client-side web application for conducting
RTT regression. Clockor2 uniquely allows users to quickly fit local and
global molecular clocks, thus handling the increasing complexity of
genomic datasets that sample beyond the assumption homogeneous host
populations. Clockor2 is efficient, handling trees of up to the order of
10^4 tips, with significant speed increases compared to other RTT
regression applications. Although clockor2 is written as a web
application, all data processing happens on the client-side, meaning that
data never leaves the user's computer. Clockor2 is freely available
at https://clockor2.github.io/