Study on transcriptome of Japanese flounder after acute high glucose stress and functional verification of critical gene SOCS3

To explore molecular targets for regulating glucose metabolism in carnivorous fish, the glucose tolerance test (GTT) was carried out on the Paralichthys olivaceus. The results of this study indicated that the down-regulation of SOSC3 enhanced the sensitivity of the insulin signaling pathway to promote glucose transport, thereby affecting gluconeogenesis and glycolysis to maintain glucose homeostasis.