Exploring the fecal microbiome dysbiosis and its plasma metabolome determinants in advanced Parkinson's disease with motor complications

Through a comprehensive clinical multi-omics analysis of Parkinson's disease patients across three distinct cohorts, specifically focusing on the gut microbiome and plasma metabolome characteristics, this study identified a series of characteristic biomarkers associated with PD-MC patients. These findings elucidate the overarching patterns of alterations in the fecal microbiome and plasma metabolome in individuals with PD-MC. Microbiome cohort, including 42 PD-MC and 66 PD without motor complications (PD-NMC); and Metabolome cohort, including 87 PD-MC and 159 PD-NMC).