Body weight, glucose and insulin levels in 4, 14 and 26 weeks db/db and Control mice as well as in 26 weeks C57Bl6 mice after 18 weeks fed with HFD.

Metabolic parameters including body weight, glucose and insulin levels were determined at the end of the experiments. Differences were detected by one-way ANOVA followed by Tuckey b or Tamhane tests as required. When we compared all groups under study we observed a significant increase in body weight as age progressed, and even higher body weights were observed in overweight mice (db/db 14 weeks old mice, db/db 26 weeks old mice and HFD treated mice), when compared to the rest of the groups [F(7,35) = 63.03, **p(7,35) = 74.36, **p(7,35) = 11.498, **p