3D cyto- and receptor architectonic map of macaque lateral premotor area F4v

A multimodal analysis of the macaque motor cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal agranular cortex, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 13 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of lateral premotor area F4v of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究针对猕猴运动皮层开展多模态分析，以构建整合并调和既往发表图谱间差异的三维图谱。研究采用可经统计学检验的定量方法分析猕猴前额叶无颗粒皮层的细胞构筑（cytoarchitecture），并结合体外定量受体放射自显影（quantitative receptor autoradiographic）技术，解析13种不同神经递质受体的区域与层状分布模式。将所识别脑区的边界标注于立体定位空间（stereotaxic space）中的猕猴标准脑模板上。本研究首次发布猕猴大脑外侧前运动皮层F4v区的图谱，该图谱整合了立体定位空间中的细胞构筑与受体构筑特征。该图谱可为非人类灵长类动物的功能实验分析提供宝贵资源，同时为基于真实突触动力学的建模研究提供关键数据。