Effect of depletion of HOIP on gene expression during B16-F10 melanoma tumor development in immunedeficinet mice.

To investigate the cooperative function LUBAC E3 ligase complex during tumor development, we established HOIP-knockout B16-F10 murine melanoma cell lines. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of the established 4 control or 4 HOIP-KO s.c tumors 2 weeks after innoculation. Comparative gene expression profiling analysis of RNA-seq data for control and HOIP-KO B16-F10 tumors.