Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500

Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500 Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase Authors: Klima, M, Silhan, J, Boura, E. Deposit date: 2023-02-02 Release date: 2023-04-05 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023猴痘病毒甲基转移酶（methyltransferase）VP39与抑制剂TO500复合物的晶体结构 描述：(2S)-2-氨基-4-[[(2S,3S,4R,5R)-5-[4-氨基-5-[2-(1H-苯并咪唑-2-基)乙炔基]吡咯并[2,3-d]嘧啶-7-基]-3,4-二羟基四氢呋喃-2-基]甲硫基]丁酸，帽结构特异性mRNA（核苷-2'-O-）-甲基转移酶 作者：Klima M、Silhan J、Boura E 沉积日期：2023-02-02 发布日期：2023-04-05 最后修改日期：2024-06-19 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.5埃） 引用文献：猴痘病毒甲基转移酶VP39抑制剂的发现与结构表征揭示其与SARS-CoV-2 nsp14甲基转移酶的相似性，《自然·通讯》，2023年，第14卷