Data for: "Investigating alternative delivery systems for self-amplifying RNA vaccines"
收藏DataCite Commons2020-07-31 更新2025-04-17 收录
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https://pureportal.strath.ac.uk/en/datasets/8d780490-8d74-466e-bb8b-32ffd60ba5c1
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资源简介：
Within this project nucleic acid based vaccine strategy – in particular self-amplifying mRNA vaccine (SAM)- has been investigated since such platform was previously reported to elicit protective immune responses, particularly in the case of cell-mediated response in a safe manner and for a variety of virus disease. In order to enhance biological stability and cell internailsation, SAM was combined with four cationic delivery systems. Oil-in-water cationic nanoemulsions (CNE), polymeric nanoparticles (NPs), lipid nanoparticles (SLNs) and liposomes were formulated in absence or in combination with a specific SAM vaccine. Despite the difference in formulation composition, all samples contained the same concentration of cationic lipid - 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP), or dimethyldioctadecylammonium (DDA) - known as immunostimulants.
提供机构：
University of Strathclyde
创建时间：
2020-02-25
