Effect of Hairy and Enhancer of Split 1 (HES1) activation on gene expression of mature osteoclasts

To investigate the role of HES1 in osteoclast differentiation and function, bone marrow-derived macrophages (BMMs) were derived from CtskCre/WT;RosaHes1 and control (Rosa[STOP]Hes1 ) mice and were differentiated into mature osteoclasts. We then performed gene expression profiling analysis using data obtained from RNA-seq of conrol and HES1-overexpressing osteoclasts. Overall design: Comparative gene expression profiling analysis of RNA-seq data for control and HES1 over-expressing osteoclasts