RSP regulates the virulence factors of Staphylococcus aureus and the key signaling pathways of the host

Staphylococcus aureus, a Gram-positive bacteria, is a human commensal bacteria that mainly colonize the nasal cavity. It is also an opportunistic pathogen that can cause clinical manifestations ranging from mild skin infection to bacteremia and endocarditis in the host. As a pathogenic microorganism, S. aureus contains a variety of virulence factors to help it infect hosts, including pore-forming toxins, superantigens and transcription factors. Four members of the AraC/XylS family of transcription factors have been experimentally characterized in S. aureus: Rbf, Rsp, AryK and HptR. Among them, Rsp can regulate biofilm formation and play an important role in mouse infection model. The regulatory roles of AraC/XylS family proteins in S. aureus are diverse, most of which remain to be explored. Previous studies in our laboratory have found that Rsp can bind to the rsp promoter to up-regulate its expression. The expression of hla, psma, and psmB can be positively regulated by directly binding to their promoter regions in an AGR-independent manner. However, the pathway of RSP regulating virulence factors in S. aureus is not complete, and the role of RSP in S. aureus infection in host is not clear. Therefore, it is necessary to further study the role of RSP in S. aureus and S. aureus invasion in host to provide targeted strategies for the treatment of bacterial infections or the preparation of vaccines against S. aureus.