Placebo response rates in double-blind placebo-controlled trials for internalized disorders in children and adolescents

*and Boulos et al, 1992;
**and Berard et al, 2006;
apossible superiority of drug vs placebo concerns the primary variable;
bthese reports are pooled analysis in which individual trials did not reveal significant treatment effect
N = number of subjects randomized in the study; Q = quality score of the report; CDRS: Children's Depression Rating Scale; CGI: Clinical Global Impression-Severity; HDRS: Hamilton Depression Rating Scale; K-SADS-dep: Schedule for Affective Disorder and Schizophrenia-depression/anhedonia subscore; MADRS: Montgomery-Asberg Depression Rating Scale; CYBOCS: Child Yale-Brown Obsessive Compulsive Scale. Placebo responders: N of responders in the placebo arm/N of subjects randomised in the placebo arm (%)