By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express distinct gene combinations. Here, we used single-cell sequencing of precisely staged embryos and devised Dist

NIAID Data Ecosystem60

Development of Multiplexed Immuno-N-Terminomics to Reveal the Landscape of Proteolytic Processing in Early Embryogenesis of Drosophila melanogaster

蛋白质水解

果蝇胚胎发育

Protein expression levels are regulated through both translation and degradation mechanisms. Levels of degradation intermediates, that is, partially degraded proteins, cannot be distinguished from tho

NIAID Data Ecosystem40

Musca domestica Transcriptome or Gene expression. Musca domestica

果蝇胚胎发育

基因表达分析

We selected four early stages of M. domestica embryogenesis and collected 100 embryos from each one. Messenger RNA was isolated from each sample. An equal mRNA mass of each sample were pooled and used

NIAID Data Ecosystem70

Spatially uniform establishment of chromatin accessibility in the early Drosophila embryo. Spatially uniform establishment of chromatin accessibility in the early Drosophila embryo

染色质可及性

果蝇胚胎发育

As the Drosophila embryo transitions from the use of maternal RNAs to zygotic transcription, domains of “open” chromatin, with relatively low nucleosome density and specific histone marks, are establi

NIAID Data Ecosystem50

HP1 drives de novo 3D genome reorganization in early Drosophila embryos

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